LIGAND-GATED ION CHANNELS
نویسندگان
چکیده
منابع مشابه
Allosteric coupling in ligand-gated ion channels
What does " allosteric " mean? In the context of receptors, the word allosteric is now widely used. It is, perhaps, not helpful for clarity of thought that different authors often use it to mean somewhat different things (Colquhoun, 1998). At one extreme, the term " allosteric antagonist " can often be translated as " we have got an antagonist and we are not sure what it does, but it appears no...
متن کاملAllosteric modulation of ligand gated ion channels by ivermectin.
Ivermectin acts as a positive allosteric regulator of several ligand-gated channels including the glutamate-gated chloride channel (GluCl), gamma aminobutyric acid type-A receptor, glycine receptor, neuronal alpha7-nicotinic receptor and purinergic P2X4 receptor. In most of the ivermectin-sensitive channels, the effects of ivermectin include the potentiation of agonist-induced currents at low c...
متن کاملFast kinetic analysis of ligand-gated ion channels.
Ligand-gated ion channels mediate fast synaptic transmission in the central and peripheral nervous system and the neuromuscular junction. Their common principle of function is the conversion of a chemical signal--neurotransmitter binding--into an electrical signal, i.e., an ion influx into the postsynaptic cell. The transient nature of this signal requires experimental setups that provide adequ...
متن کاملThe effects of general anaesthetics on ligand-gated ion channels.
The experimental effort that has been expended in investigating the effects of general anaesthetics on LGICs has been enormous over the past decade. Members of all three LGIC superfamilies have been examined using electrophysiological techniques. Anaesthetics that have been examined include volatile anaesthetics, gaseous anaesthetics, alcohols, i.v. anaesthetics and non-immobilizers. Obsolete a...
متن کاملFrom Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules
Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the target of plant and animal toxins. Together this makes toxin/receptor interactions important to d...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2011
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.2011.01649_4.x